Semaglutide injections mimic GLP-1 hormones to slow gastric emptying, reduce appetite, and promote weight loss through once-weekly subcutaneous administration. The medication works by binding to GLP-1 receptors in the brain and digestive system, signaling fullness faster and reducing overall caloric intake. Clinical trials demonstrate weight reduction averaging 15% of baseline body weight over 68 weeks when combined with lifestyle modifications.
Originally developed for diabetes management, semaglutide received FDA approval for chronic weight management in adults with BMI ≥30 kg/m² or BMI ≥27 kg/m² with weight-related medical conditions. The Singapore Health Sciences Authority approved its use under similar guidelines, requiring proper medical supervision and regular monitoring throughout treatment.
Semaglutide belongs to the GLP-1 receptor agonist class, functioning by mimicking natural incretin hormones produced in the intestines after eating. The medication binds to receptors in multiple organs, triggering a cascade of metabolic effects that support weight loss.
The primary mechanism involves delayed gastric emptying, meaning food stays in the stomach longer. This prolonged satiety reduces meal frequency and portion sizes naturally. Simultaneously, semaglutide acts on hypothalamic appetite centers, decreasing hunger signals and food cravings.
The medication also improves insulin sensitivity and glucose metabolism, beneficial for patients with prediabetes or metabolic syndrome. Beta cells in the pancreas respond better to blood glucose changes, reducing insulin resistance commonly associated with excess weight.
💡 Did You Know?
Semaglutide has a half-life of approximately 7 days, which allows for once-weekly dosing while maintaining steady therapeutic levels in the bloodstream.
Treatment begins with 0.25mg weekly for the first four weeks, allowing the body to adjust gradually. The dose increases to 0.5mg weekly for weeks 5-8, then to 1.0mg for weeks 9-12. Many patients achieve satisfactory results at 1.0mg, though some may increase to 1.7mg or the maximum 2.4mg weekly dose based on response and tolerability.
Injections use pre-filled pens with ultra-fine needles, administered subcutaneously in the abdomen, thigh, or upper arm. Rotating injection sites prevents lipodystrophy and ensures consistent absorption. The same day each week should be maintained, though timing can vary by up to 2 days if needed.
Proper injection technique involves:
Store unopened pens in the refrigerator between 2-8°C. Once opened, pens remain stable at room temperature below 30°C for 56 days. Never freeze semaglutide or expose it to direct heat or sunlight.
Gastrointestinal effects occur most frequently during initial treatment and dose escalations. Nausea affects many patients but typically improves within 4-8 weeks as tolerance develops. Eating smaller, more frequent meals and avoiding high-fat foods reduces nausea severity.
Common side effects include:
Serious but rare adverse effects require immediate medical attention:
⚠️ Important Note
Semaglutide carries a boxed warning for thyroid C-cell tumors based on rodent studies. Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use this medication.
Ideal candidates have BMI ≥30 kg/m² or BMI ≥27 kg/m² with obesity-related conditions like hypertension, dyslipidemia, or sleep apnea. Previous unsuccessful attempts at weight loss through diet and exercise alone often indicate suitability for medical intervention.
Medical evaluation includes:
Absolute contraindications include:
Relative contraindications requiring careful consideration:
Initial consultation involves comprehensive medical history, physical examination, and baseline laboratory tests. Body composition analysis using bioelectrical impedance or DEXA scanning provides accurate baseline measurements beyond simple weight.
Monthly follow-ups during dose titration assess:
Laboratory monitoring every 3-6 months includes:
Treatment duration varies individually, with many patients continuing long-term for weight maintenance. Discontinuation requires gradual dose reduction and transition to alternative weight management strategies to prevent rebound weight gain.
“Semaglutide represents a significant advancement in medical weight management, but success requires comprehensive lifestyle modification. I emphasize sustainable dietary changes focusing on protein intake and nutrient density rather than severe caloric restriction.
Patients often experience rapid initial results, but maintaining realistic expectations prevents disappointment during natural weight loss plateaus. The medication provides powerful appetite control, creating an opportunity to establish healthier eating patterns that persist beyond treatment.
Regular strength training becomes particularly important during semaglutide treatment to preserve lean muscle mass. I recommend resistance exercises at least twice weekly, adjusting intensity based on energy levels during the adaptation phase.”
How quickly will I see results with semaglutide injections?
Weight loss typically begins within 2-4 weeks, with more noticeable changes by week 8-12. Initial water weight loss occurs first, followed by steady fat reduction. Many patients lose 5-10% body weight by month 3-4 when following prescribed protocols.
Can I stop the injections once I reach my goal weight?
Discontinuing semaglutide often leads to appetite return and potential weight regain. Many patients transition to lower maintenance doses or alternative strategies. Your doctor will create an individualized plan based on your response and long-term goals.
Will semaglutide work without diet and exercise changes?
While semaglutide reduces appetite significantly, optimal results require nutritional modifications and increased physical activity. The medication creates favorable conditions for lifestyle changes but cannot overcome poor dietary choices or sedentary behavior.
What happens if I miss a dose?
Take the missed dose within 5 days. If more than 5 days pass, skip that dose and resume your regular schedule. Never double doses to compensate for missed injections.
Are the results permanent?
Weight maintenance requires ongoing effort through either continued medication at lower doses or strict adherence to lifestyle modifications. Many patients who discontinue without establishing sustainable habits experience some weight regain.
Semaglutide injection for weight loss offers significant results when combined with proper medical supervision and lifestyle modifications. Starting with careful dose titration minimizes side effects while establishing sustainable habits.
If you’re struggling with weight management despite diet and exercise efforts, our MOH-accredited aesthetic doctors can evaluate your suitability for semaglutide treatment.
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